Your browser doesn't support javascript.
loading
Effects of agonist and antagonist of cysteinyl leukotriene receptors on differentiation of rat glioma C6 cells / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences ; (6): 139-144, 2011.
Article Dans Chinois | WPRIM | ID: wpr-319819
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the role of cysteinyl leukotriene (CysLT) receptors in the differentiation of rat glioma C6 cells.</p><p><b>METHODS</b>Rat glioma C6 cells were treated with the agonist LTD(4), the CysLT(1) receptor antagonist montelukast and the differentiation inducer forskolin. Cell morphology and GFAP protein expression were determined after treatments.</p><p><b>RESULT</b>Forskolin (10 μmol/L) induced morphological changes and GFAP protein expression (cell differentiation) in C6 cells, but LTD(4) (0.1-100 nmol/L) did not induce these changes. Montelukast (1 μmol/L) alone did not affect C6 cell differentiation, while it induced the differentiation when combined with the LTD(4) (100 nmol/L).</p><p><b>CONCLUSION</b>The CysLT(2) receptor may modulate the differentiation of rat glioma C6 cells.</p>
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Anatomopathologie / Pharmacologie / Quinoléines / Colforsine / Différenciation cellulaire / Leucotriènes / Récepteurs aux leucotriènes / Leucotriène D4 / Antagonistes des leucotriènes / Cystéine Limites du sujet: Animaux langue: Chinois Texte intégral: Journal of Zhejiang University. Medical sciences Année: 2011 Type: Article

Documents relatifs à ce sujet

MEDLINE

...
LILACS

LIS

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Anatomopathologie / Pharmacologie / Quinoléines / Colforsine / Différenciation cellulaire / Leucotriènes / Récepteurs aux leucotriènes / Leucotriène D4 / Antagonistes des leucotriènes / Cystéine Limites du sujet: Animaux langue: Chinois Texte intégral: Journal of Zhejiang University. Medical sciences Année: 2011 Type: Article