Clinical significance of heterozygosity loss at Mfn2 gene in hepatocellular carcinoma / 浙江大学学报·医学版

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the loss of heterozygosity (LOH) at mitofusin-2 (Mfn2) gene in hepatocellular carcinoma (HCC) and its clinicopathological significance.</p><p><b>METHODS</b>Four high polymorphic microsatellite markers flanking Mfn2 were selected for LOH analysis in 29 cases of HCC.</p><p><b>RESULT</b>The frequencies of LOH on D1S2667, D1S2740, D1S434 and D1S228 were 21%, 23%, 21% and 22%, respectively. LOH at Mfn2 was closely correlated with tumor size, age, capsule, differentiation and t HBV infection (P<0.05), not with gender, thrombosis, cirrhosis and serum AFP levels (P>0.05).</p><p><b>CONCLUSION</b>LOH at Mfn2 gene in HCC is associated with the clinicopathological features of patients.</p>