Effect of sea cucumber cerebroside on lipid metabolism in fatty liver rats / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 493-498, 2010.
Article
Dans Chinois
| WPRIM
| ID: wpr-319870
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of sea cucumber cerebroside (SCC) on the lipid metabolism in rats with orotic acid-induced fatty liver.</p><p><b>METHODS</b>The non-alcoholic fatty liver disease (NAFLD) model was established by adding orotic acid to the diets in rats. The rats were randomly assigned to four groupscontrol group, NAFLD group, NAFLD + low SCC group and NAFLD + high SCC group. After 10 days of feeding, the serum and hepatic lipid concentrations and the aminopherase activities were measured; the composition of hepatic fatty acids was also analyzed.</p><p><b>RESULT</b>The serum TC and TG levels reduced significantly in the NAFLD group as compared with the controls (P<0.05), while the sea cucumber cereborside feeding raised the serum lipid concentrations (P<0.05). The hepatic TC and TG levels dramatically increased in the NAFLD group in comparison with the controls (P<0.05, P<0.01), while the hepatic lipid accumulations decreased in both SCC groups (P<0.05, P<0.01). The ALT and AST activities in the NAFLD group increased markedly when compared with the controls (P<0.05, P <0.01), while the sea cucumber cerebroside feeding attenuated the hepatic injury levels (P<0.05, P<0.01). Compared with the control group, the stearoyl-CoA desaturase (SCD) activity increased significantly in the NAFLD group (P<0.05), but decreased in SCC groups (P<0.05).</p><p><b>CONCLUSION</b>Sea cucumber cerebroside can attenuate the rat fatty liver induced by orotic acid.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Concombres de mer
/
Cérébrosides
/
Chimie
/
Rat Sprague-Dawley
/
Modèles animaux de maladie humaine
/
Traitement médicamenteux
/
Métabolisme lipidique
/
Acides gras
/
Stéatose hépatique
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Journal of Zhejiang University. Medical sciences
Année:
2010
Type:
Article
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