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Short-term Results of Hematopoietic Stem Cell Transplantation for Children with Myelodysplastic Syndrome
Journal of the Korean Pediatric Society ; : 370-375, 2002.
Article Dans Coréen | WPRIM | ID: wpr-32000
ABSTRACT

PURPOSE:

In most cases, myelodysplastic syndrome(MDS) transforms into a more aggressive state or acute myelogenous leukemia; it's prognosis is very poor. It is believed that hematopoietic stem cell transplantation(HSCT) is the only curative treatment of MDS, but available data in children are very sparse. In this report, the short term outcome of HSCT in childhood MDS was analyzed.

METHODS:

Ten children with MDS(CMMoL 5, RAEB 3, RAEBt 2) underwent HSCT(HLA- matched sibling transplantation 4, HLA-matched unrelated transplantation 4, cord blood transplantation 1, HLA-mismatched familial transplantation 1) between November 1995 and January 2001 at St. Mary's Hospital. Median follow-up duration was 11 months.

RESULTS:

Engraftment was successful in all cases and 8 patients are alive without disease. Three cases of VOD were observed and improved without complication. Four cases of grade II and 1 case of grade III acute GVHD were observed and well controlled with treatment. Three patients relapsed after transplantation. One patient is alive without disease after cytoreduction with allogenic stem cell rescue and 2 patients died of relapse.

CONCLUSION:

HSCT is a curative strategy of MDS and the survival rate is relatively higher than that of adults. But there is an obvious need for more studies because of the small number of patients and the short duration of the follow-up.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Pronostic / Récidive / Cellules souches / Syndromes myélodysplasiques / Anémie réfractaire avec excès de blastes / Cellules souches hématopoïétiques / Leucémie aigüe myéloïde / Taux de survie / Études de suivi / Transplantation de cellules souches hématopoïétiques Type d'étude: Étude observationnelle / Étude pronostique Limites du sujet: Adulte / Enfant / Humains langue: Coréen Texte intégral: Journal of the Korean Pediatric Society Année: 2002 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Pronostic / Récidive / Cellules souches / Syndromes myélodysplasiques / Anémie réfractaire avec excès de blastes / Cellules souches hématopoïétiques / Leucémie aigüe myéloïde / Taux de survie / Études de suivi / Transplantation de cellules souches hématopoïétiques Type d'étude: Étude observationnelle / Étude pronostique Limites du sujet: Adulte / Enfant / Humains langue: Coréen Texte intégral: Journal of the Korean Pediatric Society Année: 2002 Type: Article