Recent advances in study of sphingolipids on liver diseases / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1551-1558, 2015.
Article
Dans Chinois
| WPRIM
| ID: wpr-320043
ABSTRACT
Sphingolipids, especially ceramide and S1P, are structural components of biological membranes and bioactive molecules which participate in diverse cellular activities such as cell division, differentiation, gene expression and apoptosis. Emerging evidence demonstrates the role of sphingolipids in hepatocellular death, which contributes to the progression of several liver diseases including ischaemia-reperfusion liver injury, steatohepatitis or hepatocarcinogenesis. Furthermore, some data indicate that the accumulation of some sphingolipids contributes to the hepatic dysfunctions. Hence, understanding of sphingolipid may open up a novel therapeutic avenue to liver diseases. This review focuses on the progress in the sphingolipid metabolic pathway with a focus on hepatic diseases and drugs targeting the sphingolipid pathway.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Sphingolipides
/
Sphingosine
/
Lysophospholipides
/
Lésion d'ischémie-reperfusion
/
Céramides
/
Apoptose
/
Stéatose hépatique
/
Maladies du foie
/
Métabolisme
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2015
Type:
Article
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