Advances in the study of site-specific antibody-drug conjugates / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1225-1231, 2015.
Article
Dans Chinois
| WPRIM
| ID: wpr-320097
ABSTRACT
Antibody drug conjugates (ADCs) are an emerging class of targeted therapeutics with the potential to improve therapeutic index over the traditional chemotherapy. However, it is difficult to control the site and stoichiometry of conjugation in mAb, typically resulting in heterogeneous mixtures of ADCs that are difficult to optimize. New methods for site-specific drug attachment allow development of more homogeneous conjugates and control of the site of drug attachment. In this article, the new literature on development of ADCs and site-specific ADCs is reviewed. In addition, we summarized the various strategies in production of site-specific ADCs.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Sites de fixation des anticorps
/
Chimie
/
Immunoconjugués
/
Anticorps monoclonaux
/
Spécificité des anticorps
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2015
Type:
Article
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