Ras-MAPK signaling pathway activated via brain-derived neurotrophic factor / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 915-918, 2006.
Article
Dans Chinois
| WPRIM
| ID: wpr-320453
ABSTRACT
Brain-derived neurotrophic factor (BDNF)is the richest neurophin in brain tissue and may act as an activity-dependent neuronal survival factor. In vitro, BDNF plays an important role in preventing cortical neurons from hypoxia-induced neurotoxicity. It could induce a variety of cellular responses such as cell growth, survival, differentiation, and anti-apoptosis mainly via activating mitogen-activated protein kinase (MAPK) and Ca2+/calmodulin-dependent kinase (CaMK) signaling pathways. And among these multiple signaling pathways there is growing evidence of complicated cross talk.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Physiologie
/
Transduction du signal
/
Cellules cultivées
/
Calcium-Calmodulin-Dependent Protein Kinases
/
Facteur neurotrophique dérivé du cerveau
/
Mitogen-Activated Protein Kinases
/
Biologie cellulaire
/
Calcium-Calmodulin-Dependent Protein Kinase Type 2
/
Neurones
Limites du sujet:
Animaux
/
Humains
langue:
Chinois
Texte intégral:
Journal of Biomedical Engineering
Année:
2006
Type:
Article
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