Targeted therapy: tailoring cancer treatment / 癌症
Chinese Journal of Cancer
;
(12): 363-364, 2013.
Article
Dans Anglais
| WPRIM
| ID: wpr-320568
ABSTRACT
Targeted therapies include small-molecule inhibitors and monoclonal antibodies, have made treatment more tumor-specific and less toxic, and have opened new possibilities for tailoring cancer treatment. Nevertheless, there remain several challenges to targeted therapies, including molecular identification, drug resistance, and exploring reliable biomarkers. Here, we present several selected signaling pathways and molecular targets involved in human cancers including Aurora kinases, PI3K/mTOR signaling, FOXO-FOXM1 axis, and MDM2/MDM4-p53 interaction. Understanding the molecular mechanisms for tumorigenesis and development of drug resistance will provide new insights into drug discovery and design of therapeutic strategies for targeted therapies.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Thérapeutique
/
Protéines nucléaires
/
Transduction du signal
/
Protéine p53 suppresseur de tumeur
/
Protéines proto-oncogènes
/
Résistance aux médicaments antinéoplasiques
/
Phosphatidylinositol 3-kinases
/
Protéines proto-oncogènes c-mdm2
/
Facteurs de transcription Forkhead
/
Sérine-thréonine kinases TOR
Type d'étude:
Étude pronostique
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Chinese Journal of Cancer
Année:
2013
Type:
Article
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