Lymphoma and cerebral vasculitis in association with X-linked lymphoproliferative disease / 癌症
Chinese Journal of Cancer
;
(12): 673-677, 2013.
Article
Dans Anglais
| WPRIM
| ID: wpr-320576
ABSTRACT
Lymphoma is seen in up to 30% of patients with X-linked lymphoproliferative disease (XLP), but cerebral vasculitis related with XLP after cure of Burkitt lymphoma is rarely reported. We describe a case of a 5-year-old boy with XLP who developed cerebral vasculitis two years after cure of Burkitt lymphoma. He had Burkitt lymphoma at the age of 3 years and received chemotherapy (non-Hodgkin's lymphoma-Berlin-Frankfurt-Milan-90 protocol plus rituximab), which induced complete remission over the following two years. At the age of 5 years, the patient first developed headache, vomiting, and then intellectual and motorial retrogression. His condition was not improved after anti-infection, dehydration, or dexamethasone therapy. No tumor cells were found in his cerebrospinal fluid. Magnetic resonance imaging showed multiple non-homogeneous, hypodense masses along the bilateral cortex. Pathology after biopsy revealed hyperplasia of neurogliocytes and vessels, accompanied by lymphocyte infiltration but no tumor cell infiltration. Despite aggressive treatment, his cognition and motor functions deteriorated in response to progressive cerebral changes. The patient is presently in a vegetative state. We present this case to inform clinicians of association between lymphoma and immunodeficiency and explore an optimal treatment for lymphoma patients with compromised immune system.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Imagerie par résonance magnétique
/
Protocoles de polychimiothérapie antinéoplasique
/
Lymphome de Burkitt
/
Résultat thérapeutique
/
Vascularite du système nerveux central
/
Utilisations thérapeutiques
/
Traitement médicamenteux
/
Anticorps monoclonaux d'origine murine
/
Rituximab
/
Syndromes lymphoprolifératifs
Type d'étude:
Guide de pratique
Limites du sujet:
Enfant d'âge préscolaire
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Chinese Journal of Cancer
Année:
2013
Type:
Article
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