Association between the single nucleotide polymorphisms of human CD36 gene and acute coronary syndrome / 中华流行病学杂志

ABSTRACT

<p><b>OBJECTIVE</b>The aim of the present study was to assess the association between the polymorphisms of CD36 gene and acute coronary syndrome(ACS).</p><p><b>METHODS</b>Genotypes of CD36 single nucleotide polymorphisms were detected under PCR-RFLP in 522 patients with ACS and 1 215 controls.</p><p><b>RESULTS</b>For people under Han and Uygur ethnicities, the distribution of genotypes and allele of rs1722505 was significantly different between ACS and the controls(all P < 0.05). For Han population, the frequency of A allele of rs17154181 was significantly lower in ACS group than that in the control group(P = 0.034). Results from logistic regression analysis showed that the AA+AG genotype of rs1722505 was significantly higher in ACS patients than that in controls both between the Hans and the Uygurs(OR = 1.436, 95%CI1.047-1.970, P = 0.025;OR = 1.589, 95%CI1.009-2.473, P = 0.046, respectively). For Han people,AA+AG genotype of rs17154181 was significantly lower in ACS patients than that in controls(OR = 0.667, 95% CI0.494-0.900, P = 0.008).</p><p><b>CONCLUSION</b>Data from the present study suggested that the CD36 gene might serve as a genetic marker of ACS in both Han and Uygur populations.</p>