ROS kinase fusions are not common in Chinese patients with cholangiocarcinoma / 南方医科大学学报
Journal of Southern Medical University
;
(12): 474-478, 2013.
Article
Dans Anglais
| WPRIM
| ID: wpr-322019
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expressions of different forms of ROS fusions in Chinese patients with cholangiocarcinoma (CCA).</p><p><b>METHODS</b>RT-PCR was employed to examine formalin-fixed and paraffin-embedded CCA samples from stage I-IV patients for detection of ROS fusions involving Fused in Glioblastoma (FIG), solute carrier protein (SLC34A2) and major histocompatibility complex class II invariant chain (CD74). Serpin peptidase inhibitor clade A member 1 (SERPINA1) was detected as the reference gene.</p><p><b>RESULTS</b>In all the 56 CCA samples, 80.4% (45/56) were positive for SERPINA1 expression as evaluable samples. Of these evaluable samples, none expressed the ROS fusions.</p><p><b>CONCLUSION</b>ROS fusions are not common in Chinese CCA patients.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Tumeurs des canaux biliaires
/
Protein-tyrosine kinases
/
Protéines de transport
/
Antigènes de différenciation des lymphocytes B
/
Antigènes d'histocompatibilité de classe II
/
Expression des gènes
/
Protéines de fusion oncogènes
/
Protéines proto-oncogènes
/
Inclusion en paraffine
Limites du sujet:
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Journal of Southern Medical University
Année:
2013
Type:
Article
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