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The expression and significance of receptor activator of nuclear factor kappaB ligand and osteoprotegerin in periapical cyst and periapical granuloma / 华西口腔医学杂志
West China Journal of Stomatology ; (6): 360-363, 2012.
Article Dans Chinois | WPRIM | ID: wpr-322383
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of receptor activator of nuclear factor kappaB ligand (RANKL) and osteoprotegerin (OPG) in periapical cyst and periapical granuloma by comparison with the expression in the normal periodontal tissue as control, and to identify their functional mechanism in the bone destruction of periapical cyst and granuloma.</p><p><b>METHODS</b>20 periapical cyst tissues (cyst group), 20 periapical granuloma tissues (granuloma group), and 20 normal periodontal tissues (control group) were collected respectively. Immunohistochemical technology was performed to detect the expression of RANKL and OPG in above three groups.</p><p><b>RESULTS</b>In cyst group, granuloma group and control group, the expression of RANKL were 75.00 +/- 7.54, 68.40 +/- 6.74 and 29.40 +/- 2.46, respectively. The expression of OPG were 38.10 +/- 7.09, 47.65 +/- 13.85 and 58.60 +/- 5.88, respectively. The differences among the three groups were statistically significant (P<0.05). RANKL and OPG in cysts group were negatively correlated (r=-0.56, P=0.01) and were not correlated with granuloma and control group (P>0.05).</p><p><b>CONCLUSION</b>RANKL and OPG play roles in the bone absorption of periapical disease. In periapical disease, abnormal expression of RANKL and OPG are detected, RANKL significantly increase, OPG decrease, bone absorption accelerate and osteolytic lesion are observed. In periapical cyst, the bone absorption is more active compared with periapical granuloma.</p>
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Granulome périapical / Kyste radiculaire / Ligand de RANK / Récepteur activateur du facteur nucléaire Kappa B / Ostéoprotégérine Type d'étude: Étude pronostique Limites du sujet: Humains / Mâle langue: Chinois Texte intégral: West China Journal of Stomatology Année: 2012 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Granulome périapical / Kyste radiculaire / Ligand de RANK / Récepteur activateur du facteur nucléaire Kappa B / Ostéoprotégérine Type d'étude: Étude pronostique Limites du sujet: Humains / Mâle langue: Chinois Texte intégral: West China Journal of Stomatology Année: 2012 Type: Article