Chemical approaches for trapping protein thiols and their oxidative modification / 药学学报
Acta Pharmaceutica Sinica
;
(12): 280-290, 2012.
Article
Dans Chinois
| WPRIM
| ID: wpr-323045
ABSTRACT
Redox signal transduction, especially the oxidative modification of proein thiols, correlates with many diseases and becomes an expanding research area. However, there was rare method for quick and specific detection of protein thiols and their oxidative modification in living cells. In this article, we review the current chemical strategies for the detection and quantification of protein thiols and related cysteine oxidation. We also look into the future of the development of fluorescent probes for protein thiols and their potential application in the research of reactive cysteine proteomes and early detection of redox-related diseases.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Oxydoréduction
/
Acides sulféniques
/
Thiols
/
Protéines
/
Nitrosation
/
Chimie
/
Espèces réactives de l'oxygène
/
Cystéine
/
Espèces réactives de l'azote
/
Colorants fluorescents
Type d'étude:
Étude de dépistage
Limites du sujet:
Animaux
/
Humains
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2012
Type:
Article
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