Synthesis and anti-tumor activity of paeonol and its derivatives / 药学学报
Acta Pharmaceutica Sinica
; (12): 72-76, 2012.
Article
de Zh
| WPRIM
| ID: wpr-323078
Bibliothèque responsable:
WPRO
ABSTRACT
A series of paeonol derivatives have been synthesized by simple acylation and etherification of the paeonol. Anti-tumor activities of the synthesized compounds were evaluated against HeLa and MCF-7 cells lines in vitro by the standard MTT assay. It was found that the derivatives were more active against HeLa than MCF-7. The results also indicated that 4-methoxy group is the synergistic group of paeonol's anti-tumor activity and ketone carbonyl side chain is essential functional group of paeonol's anti-tumor activity. Compound 2d had stronger antiproliferative activities than paeonol against HeLa and MCF-7 cell lines with IC50 values of 2.67 and 4.74 micromol x L(-1) respectively. The results showed that paeonol derivatives were worth to be intensively studied further.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Acétophénones
/
Pharmacologie
/
Relation structure-activité
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Tests de criblage d'agents antitumoraux
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Cellules HeLa
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Chimie
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Concentration inhibitrice 50
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Prolifération cellulaire
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Cellules MCF-7
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Antinéoplasiques d'origine végétale
Limites du sujet:
Humans
langue:
Zh
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2012
Type:
Article