M cell in vitro model and its application in oral delivery of macromolecular drugs / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1429-1435, 2011.
Article
Dans Chinois
| WPRIM
| ID: wpr-323106
ABSTRACT
The oral administration of bioactive macromolecular drugs such as proteins, peptides and nucleic acids represents unprecedented challenges from the drug delivery point of view. One key consideration is how to overcome the gastrointestinal tract absorption barrier. Recent studies suggest that microfold cell (M cell), a kind of specialized antigen-sampling epithelial cell which is characterized by a high endocytic rate and low degradation ability, may play an important role in macromolecule oral absorption. The development of an in vitro M cell coculture system and its modified models greatly advanced the study of M cells and the development of oral delivery system for macromolecular drugs. The special structure, function and formation characteristics, and biomarkers of M cell are summarized in this review. The applications of in vitro M cell models in developing oral delivery system ofbioactive macromolecular drugs are discussed.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Peptides
/
Plaques de Peyer
/
Pharmacocinétique
/
Vaccins
/
Protéines
/
Administration par voie orale
/
Systèmes de délivrance de médicaments
/
Biologie cellulaire
/
Structures macromoléculaires
/
Muqueuse intestinale
Type d'étude:
Étude pronostique
Limites du sujet:
Animaux
/
Humains
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2011
Type:
Article
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