Correlation between PTPN22 gene polymorphism and systemic lupus erythematosus in Chinese Han patients / 南方医科大学学报
Journal of Southern Medical University
;
(12): 2390-2391, 2010.
Article
Dans Chinois
| WPRIM
| ID: wpr-323652
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between 1858C/T single nucleotide polymorphism on exon 14 of the protein tyrosine phosphatase nonreceptor-22 (PTPN22) gene and systemic lupus erythematosus in Chinese Han patients.</p><p><b>METHODS</b>Forty Chinese Han patients with SLE and 20 normal control subjects were enrolled in the study, and PTPN22 gene 1858 C/T polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).</p><p><b>RESULTS</b>No significant difference was found in the CC, CT, and TT genotype frequencies or in the C and T allele frequencies between the SLE patients and the normal controls.</p><p><b>CONCLUSION</b>1858C/T on PTPN22 gene might not be associated with the susceptibility of SLE in Chinese Han population.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Études cas-témoins
/
Exons
/
Prédisposition génétique à une maladie
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Polymorphisme de nucléotide simple
/
Asiatiques
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Protein Tyrosine Phosphatase, Non-Receptor Type 22
/
Fréquence d'allèle
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Génétique
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Génotype
/
Lupus érythémateux disséminé
Type d'étude:
Étude observationnelle
/
Facteurs de risque
Limites du sujet:
Adolescent
/
Adulte
/
Enfant
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Journal of Southern Medical University
Année:
2010
Type:
Article
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