T cell receptor constant alpha chain gene +1592C/T polymorphism may not be associated with IgA nephropathy / 南方医科大学学报
Journal of Southern Medical University
;
(12): 2298-2300, 2010.
Article
Dans Chinois
| WPRIM
| ID: wpr-323677
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between T cell receptor constant alpha chain (TCRCα) gene +1592C/T polymorphism and IgA nephropathy.</p><p><b>METHODS</b>TCRCα +1592C/T genotypes were identified by PCR-RFLP and direct sequencing in 244 Chinese Han patients with IgA nephropathy, who were classified according to their genotype into CC (188 cases), CT (54 cases) and TT (2 cases) groups. The clinical and pathological data of the patients were analyzed in relation to the TCRCα +1592C/T genotypes.</p><p><b>RESULTS</b>No significant differences in the clinical and biochemical indices were found in these patients with different TCRCα gene +1592C/T genotypes. TCRCα +1592C/T polymorphism was not found to contribute to severity or manifestations of renal pathology.</p><p><b>CONCLUSIONS</b>TCRCα+1592C/T polymorphism may not be associated with the susceptibility to IgA nephropathy in the Chinese Han population.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Chromosomes humains de la paire 14
/
Polymorphisme de restriction
/
Récepteur lymphocytaire T antigène, alpha-bêta
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Polymorphisme de nucléotide simple
/
Asiatiques
/
Fréquence d'allèle
/
Génétique
/
Génotype
/
Glomérulonéphrite à dépôts d'IgA
Limites du sujet:
Adolescent
/
Adulte
/
Enfant
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Journal of Southern Medical University
Année:
2010
Type:
Article
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