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Role of liver X receptors on cardiomyocyte hypertrophy / 中华心血管病杂志
Chinese Journal of Cardiology ; (12): 1119-1123, 2009.
Article Dans Chinois | WPRIM | ID: wpr-323898
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of liver X receptors (LXR) in hypertrophic myocardium and the effect of LXR agonist T0901317 on angiotensin II (AngII) induced cardiomyocyte hypertrophy.</p><p><b>METHODS</b>Transverse aortic coarctation (TAC) or sham operation were performed in 2-month-old wide type mice (C57/B6). Two weeks later, the expression of LXR in myocardium was detected by quantitative real-time PCR analysis and Western blot analysis. The effect of LXR agonist T0901317 on AngII-induced hypertrophy in cultured neonatal rat cardiomyocytes was also assessed.</p><p><b>RESULTS</b>Quantitative real-time PCR analysis and Western blot analysis showed that LXRalpha but not LXRbeta expression was upregulated post TAC both at mRNA and protein levels (All P < 0.05). AngII induced increased [(3)H] leucine incorporation and cardiomyocyte hypertrophy were significantly reduced by T0901317 in a dose-dependent manner (P < 0.05). T0901317 also dose-dependently inhibited atrial natriuretic peptide (ANP) gene expression in cardiomyocytes (P < 0.05).</p><p><b>CONCLUSION</b>Our findings strongly suggest that LXR is a potent mediator of cardiomyocyte hypertrophy and LXR activation could attenuate AngII induced cardiomyocyte hypertrophy in vitro.</p>
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Anatomopathologie / Pharmacologie / Sulfonamides / Angiotensine-II / Cellules cultivées / Myocytes cardiaques / Récepteurs nucléaires orphelins / Récepteurs hépatiques X / Hydrocarbures fluorés / Animaux sauvages Limites du sujet: Animaux langue: Chinois Texte intégral: Chinese Journal of Cardiology Année: 2009 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Anatomopathologie / Pharmacologie / Sulfonamides / Angiotensine-II / Cellules cultivées / Myocytes cardiaques / Récepteurs nucléaires orphelins / Récepteurs hépatiques X / Hydrocarbures fluorés / Animaux sauvages Limites du sujet: Animaux langue: Chinois Texte intégral: Chinese Journal of Cardiology Année: 2009 Type: Article