Effects of atorvastatin, alone and in combination with probucol on endothelial function in patients with acute coronary syndrome / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 900-903, 2009.
Article
Dans Chinois
| WPRIM
| ID: wpr-323926
ABSTRACT
<p><b>OBJECTIVES</b>To evaluate the effects of combined atorvastatin and probucol use on endothelial function in patients with acute coronary syndrome (ACS).</p><p><b>METHODS</b>Thirty patients with ACS were randomized to receive atorvastatin (20 mg/d) and probucol (500 mg/d, combination group, n = 15) or atorvastatin (20 mg/d) alone (atorvastatin group) within 24 h after admission for 4 weeks. Endothelium-dependent flow-mediated dilatation (FMD) and endothelium-independent sublingual nitroglycerin-mediated dilatation (NMD) as well as the levels of lipids and C-reactive protein were assessed at baseline, 1 week and 4 weeks after therapy.</p><p><b>RESULTS</b>Compared to baseline, the levels of total cholesterol, LDL-C and C-reactive protein were significantly reduced after 1 week and 4 weeks in both groups, FMD equally increased after 1 week in both groups (atorvastatin group 3.75% +/- 0.78% vs. 1.09% +/- 0.44%, combination group 3.67% +/- 0.36% vs. 1.24% +/- 0.37%, P < 0.01). Post 4 weeks therapy, FMD increase was significantly higher in combination group (3.67% +/- 0.36% at 1 week vs. 6.85% +/- 0.64% at 4 weeks, P < 0.01) than that in atorvastatin group (3.75% +/- 0.78% vs. 3.80% +/- 0.31%, P = 0.954). NMD also equally and increased over 4 weeks in two groups (P < 0.01 vs. baseline). There was no correlation between the change in FMD/NMD and the changes in lipids or C-reactive protein levels.</p><p><b>CONCLUSIONS</b>The combined atorvastatin and probucol therapy early after ACS is superior to atorvastatin alone on improving endothelial function.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Probucol
/
Pyrroles
/
Sang
/
Protéine C-réactive
/
Endothélium vasculaire
/
Utilisations thérapeutiques
/
Traitement médicamenteux
/
Association de médicaments
/
Syndrome coronarien aigu
/
Atorvastatine
Type d'étude:
Essai clinique contrôlé
Limites du sujet:
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Cardiology
Année:
2009
Type:
Article
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