De novo salivary malignant myoepithelioma: pathologic diagnosis of 19 cases / 中华口腔医学杂志
Chinese Journal of Stomatology
;
(12): 287-290, 2004.
Article
Dans Chinois
| WPRIM
| ID: wpr-324169
ABSTRACT
<p><b>OBJECTIVE</b>To study the pathological characteristics of salivary malignant myoepithelioma with characteristic multinodular architecture.</p><p><b>METHODS</b>To observe the histologic and cytologic characteristics of 19 cases of de novo salivary malignant myoepithelioma with multinodular growth pattern. Immunohistochemistry of calponin, SMA, S-100, GFAP, cytokeratin, PCNA was done on 11 cases and ultrastructure was observed on 3 cases.</p><p><b>RESULTS</b>19 tumors presented characteristic multinodular growth pattern, mostly accompanied by central necrosis. Neoplastic nests invaded the surrounding normal tissue and tumor cells displayed a variety of pleomorphism. Epitheliod cell was the most predominant cell type. Tumor-related extracellular matrix formation was revealed among tumor cells. Immunohistochemical staining demonstrated that the tumor cells were positive for calponin, SMA, S-100, GFAP, AE1/AE3, CKH and PCNA. Myofilaments were found in neoplastic cell cytoplasm under the electron microscope.</p><p><b>CONCLUSION</b>Histologic and cytologic observation, immunostaining and ultrastructural study all supported the myoepithelial and malignant nature of the tumor.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Tumeurs de la parotide
/
Tumeurs des glandes salivaires
/
Myoépithéliome
/
Diagnostic
/
Diagnostic différentiel
Type d'étude:
Etude diagnostique
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Stomatology
Année:
2004
Type:
Article
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