Polymorphism of XRCC1 and chromosome damage in workers occupationally exposed to benzene / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
;
(12): 423-427, 2012.
Article
Dans Chinois
| WPRIM
| ID: wpr-324234
ABSTRACT
<p><b>OBJECTIVE</b>To explore the relationship between the polymorphisms of DNA repair gene (XRCC1 194, 280 and 399) and the chromosomal damage induced by benzene.</p><p><b>METHODS</b>The chromosomal damage of the peripheral lymphocytes in 459 workers occupationally exposed to benzene and 88 non-exposed controls were detected with cytokinesis-block micronucleus (CBMN) assay. PCR-RFLP technique was used to measure polymorphisms in XRCC1 194, 280 and 399.</p><p><b>RESULTS</b>It was found that the MN frequency (2.12‰ ± 1.88‰) of the exposed group was significantly higher than that (1.19‰ ± 1.68‰) of the control group (P < 0.05), in the exposed group, the MN frequency (3.00‰ ± 2.76‰) of older workers (> 35 years) was significantly higher than that (2.02‰ ± 1.71‰) of younger workers (≤ 35 years) (P < 0.05). The effect of genetic polymorphisms of XRCC1 on CBMN was not found. The haplotypes AAA/BAA, AAB/AAB, ABA/ABA, ABB/ABB could associated with the increased frequencies of total micronucleus (P < 0.05).</p><p><b>CONCLUSION</b>Benzene exposure could result in chromosome damage. Age of workers and diplotypes of XRCC1 could associated with chromosomal damage induced by benzene.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Benzène
/
Altération de l'ADN
/
Tests de micronucleus
/
Exposition professionnelle
/
Polymorphisme de nucléotide simple
/
Micronoyaux à chromosomes défectueux
/
Protéines de liaison à l'ADN
/
Protéine-1 de complémentation croisée de la réparation des lésions induites par les rayons X
/
Génétique
Limites du sujet:
Adulte
/
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Année:
2012
Type:
Article
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