Study on release mechanism of berberine hydrochloride-loaded carboxymethyl konjac glucomannan pellets for colonic delivery / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 23-26, 2008.
Article
Dans Chinois
| WPRIM
| ID: wpr-324307
ABSTRACT
<p><b>OBJECTIVE</b>To study release mechanism of berberine hydrochloride (BH) from carboxymethyl konjac glucomannan pellets for colonic delivery.</p><p><b>METHOD</b>The pellets were prepared by ionotropic gelation technique. The effects of the kinds of enzyme and enzyme concentration of dissolution media on the release of BH and the erosion properties of the pellets were studied.</p><p><b>RESULT</b>Compared with the dissolution media without enzymes, the release of BH and the erosion of the pellets were increased obviously in the media with rat cecal and colonic content or beta-mannase, the degradation of the carrier material of pellets by enzymes was the main factor which result in the erosion of the pellets. With the increased of beta-mannase concentration, the release of BH and the erosion of the pellets increased, the amount relationships of the release of BH and the erosion of the pellets were approximately 11. The release of BH exhibit Peppas equation, the n value was more than 1.</p><p><b>CONCLUSION</b>The release mechanism of BH from the pellets was enzymatic erosion-controlled, which indicates the potential of the pellets to serve as a colon-specific drug delivery system.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Berbérine
/
Transport biologique
/
Pharmacocinétique
/
Chimie
/
Systèmes de délivrance de médicaments
/
Rat Sprague-Dawley
/
Côlon
/
Beta-Mannosidase
/
Mannanes
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
China Journal of Chinese Materia Medica
Année:
2008
Type:
Article
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