Effect of Q-switched Alexandrite laser irradiation on epidermal melanocytes in treatment of Nevus of Ota / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 597-601, 2003.
Article
Dans Anglais
| WPRIM
| ID: wpr-324383
ABSTRACT
<p><b>OBJECTIVE</b>To investigate injury to epidermal melanocyte by Q-switched Alexandrite laser.</p><p><b>METHODS</b>Multiple biopsies were performed on 5 patients with nevus of Ota from before irradiation to 1 year after irradiation. Fourteen specimens were obtained for light microscopy, and 17 for transmission electron microscopy.</p><p><b>RESULTS</b>Melanosomes in epidermal melanocytes were both smaller in size and fewer in number than those in dermal melanocytes. Immediately after irradiation, focal extracellular vacuoles of the basal layer could be observed under light microscopy. Most epidermal melanocytes underwent mild or moderate injury in the form of vacuolated melanosomes, swollen mitochondria, dilation of endoplasmic reticulum, and expansion of extracellular space, retaining intact cell membranes. Normal structures were restored 5 months to 1 year after irradiation, with no depigmentation or hyperpigmentation as seen by light microscopy.</p><p><b>CONCLUSION</b>Injury of melanosomes in epidermal melanocytes is reversible.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Effets des rayonnements
/
Radiothérapie
/
Tumeurs cutanées
/
Béryllium
/
Microscopie électronique
/
Naevus de Ota
/
Utilisations thérapeutiques
/
Thérapie laser
/
Lasers
Limites du sujet:
Adolescent
/
Adulte
/
Femelle
/
Humains
langue:
Anglais
Texte intégral:
Chinese Medical Journal
Année:
2003
Type:
Article
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