Beta-carotene protects rats against bronchitis induced by cigarette smoking / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 514-516, 2003.
Article
Dans Anglais
| WPRIM
| ID: wpr-324400
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the protective effects of beta-carotene in rats against the development of chronic bronchitis induced by cigarette smoking.</p><p><b>METHODS</b>Forty-two Male Wistar rats were randomly divided into three study groups (1) control (n = 15), animals underwent no treatment; (2) cigarette smoking (n = 15), animals developed chronic bronchitis through long-term cigarette smoking twice a day for 75 d; (3) beta-carotene plus cigarette smoking animals (n = 12) were given 1 ml or 15 mg/kg beta-carotene orally every day just before cigarette smoking. The levels of IL-6, IL-8, NO, superoxide dismutase (SOD) and lipoperoxide (LPO) in serum, bronchoalveolar lavage fluid (BALF) and lung tissue were measured and the pathological changes to lung tissue were analyzed using light microscopy.</p><p><b>RESULTS</b>Long-term cigarette smoking caused an obvious increase in the amount of IL-6, IL-8 and LPO and a sharp decrease in the levels of NO and SOD in smoking animals compared to controls. beta-carotene intake reversed all the changes induced by smoking and alleviated the pathological changes caused by chronic bronchitis.</p><p><b>CONCLUSIONS</b>Quantitative oral intake of beta-carotene had protective effects against chronic bronchitis induced by long-term cigarette smoking, which was associated with the increased production of NO, the clearance of some oxidative free radicals (OFR) and the alleviation of chronic inflammation.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Superoxide dismutase
/
Sang
/
Bronchite
/
Fumer
/
Interleukine-8
/
Interleukine-6
/
Rat Wistar
/
Bêtacarotène
/
Monoxyde d'azote
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Chinese Medical Journal
Année:
2003
Type:
Article
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