Expression of peroxiredoxin III in cervical lesions / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 443-445, 2009.
Article
Dans Chinois
| WPRIM
| ID: wpr-325517
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression feature of peroxiredoxin III in cervical lesions and to further understand the mechanism for cervical cancer development/progression.</p><p><b>METHODS</b>Expression of peroxiredoxin III was immunohistochemically detected in cervical cancer. In addition, cervical epithelia were transfected with recombinant adeno-associated virus vector containing human papillomavirus 16 E6/E7 and peroxiredoxin III expression was detected by quantitative real time PCR and Western blotting.</p><p><b>RESULTS</b>Peroxiredoxin III was significantly up-regulated in cervical cancer tissues. Nevertheless, expression of peroxiredoxin III remained unchanged in cervical epithelial cells after transfection.</p><p><b>CONCLUSION</b>It seems that Prx III is not related to cervical cancer initiation. Up-regulation of peroxiredoxin III in cervical cancer might be an active response to oxidative stress in malignant cells, which protects against oxidatiton-induced apoptosis.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Protéines de répression
/
Virologie
/
Régulation de l'expression des gènes tumoraux
/
Régulation positive
/
Tumeurs du col de l'utérus
/
Col de l'utérus
/
Protéines des oncogènes viraux
/
Papillomavirus humain de type 16
/
Protéines E7 de papillomavirus
/
Peroxirédoxines
Limites du sujet:
Femelle
/
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Experimental and Clinical Virology
Année:
2009
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS