Study on the association between severe chronic hepatitis B and HLA-DRB1 gene polymorphism / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
; (6): 364-366, 2009.
Article
de Zh
| WPRIM
| ID: wpr-325540
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the association between HLA-DRB1 gene polymorphism and severe chronic hepatitis B.</p><p><b>METHODS</b>26 patients with severe chronic hepatitis B were investigated for HLA-DRB1 gene polymorphism by polymerase chain reaction-sequence specific primers technique. The results were compared with those from 45 normal healthy people by use of chi2-test of Microsoft SPSS 13.0.</p><p><b>RESULTS</b>The frequency of HLA-DRB1 * 1301/1302 allele in severe chronic hepatitis B group was significantly higher than the frequency in the control group, while the frequencies of HLA-DRB1 * 1201/1202, 1501/1502 allele were not significantly different.</p><p><b>CONCLUSION</b>HLA-DRB1 * 1301,1302 is closely associated with the suseptibility to severe chronic hepatitis B, While HLA-DRB1 * 1201/1202, 1501/1502 have no association with severe chronic hepatitis B.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Anatomopathologie
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Physiologie
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Polymorphisme génétique
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Virologie
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Indice de gravité de la maladie
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Antigènes HLA-DR
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Études cas-témoins
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Virus de l'hépatite B
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Hépatite B chronique
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Chaines HLA-DRB1
Type d'étude:
Observational_studies
/
Risk_factors_studies
Limites du sujet:
Adult
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Female
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Humans
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Male
langue:
Zh
Texte intégral:
Chinese Journal of Experimental and Clinical Virology
Année:
2009
Type:
Article