Relationship between methimazole and antineutrophil cytoplasmic antibody-positive vasculitis / 中华儿科杂志
Chinese Journal of Pediatrics
;
(12): 446-449, 2008.
Article
Dans Chinois
| WPRIM
| ID: wpr-326117
ABSTRACT
<p><b>OBJECTIVE</b>To study the relationship between methimazole (MMI) and antineutrophil cytoplasmic antibody (ANCA)-positive vasculitis.</p><p><b>METHODS</b>Thirty-three cases with Graves' disease were tested for serum ANCA before and after taking MMI. At the same time, clinicopathological data of two patients with Graves' disease who had antineutrophil cytoplasmic antibody-positive vasculitis during treatment with MMI were analyzed.</p><p><b>RESULTS</b>Two patients developed antineutrophil cytoplasmic antibody-positive vasculitis during the medication with MMI for 5-6 years; their major clinical manifestations were hematuria and renal failure. Renal biology showed renal vasculitis and vascular necrosis. The disease was relieved after treatment with immunosuppressor. Serum ANCA in the 33 cases was negative before taking MMI. In 3 cases serum ANCA became positive after taking MMI for 2 months, 3 months and 2 years, respectively. The positive rate is 9% (3/33). The major finding was microscopic hematuria. ANCA positive rate was significantly higher after taking MMI than that before taking MMI (chi2) = 5.3, P < 0.05). Microscopic hematuria disappeared after general treatment.</p><p><b>CONCLUSION</b>There may be a relationship between methimazole and development of antineutrophil cytoplasmic antibody-positive vasculitis. Renal impairment can occur. The signs and symptoms of the vasculitis can disappear after proper treatment.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Antithyroïdiens
/
Vascularite
/
Sang
/
Maladie de Basedow
/
Anticorps anti-cytoplasme des polynucléaires neutrophiles
/
Utilisations thérapeutiques
/
Traitement médicamenteux
/
Rein
/
Thiamazol
Limites du sujet:
Adolescent
/
Enfant
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Pediatrics
Année:
2008
Type:
Article
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