The relationship between FHIT and WWOX expression and clinicopathological features in hepatocellular carcinoma / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 357-360, 2010.
Article
Dans Chinois
| WPRIM
| ID: wpr-326360
ABSTRACT
<p><b>OBJECTIVE</b>To study the relationship between FHIT and WWOX expression and clinicopathological features in hepatocellular carcinoma (HCC).</p><p><b>METHOD</b>The expression of FHIT and WWOX were determined by immunohistochemistry in 142 patients with HCC.</p><p><b>RESULTS</b>Absent or reduced FHIT and WWOX expression was observed in 68.3% and 77.5% of HCCs, respectively. The expression of FHIT was significantly correlated with that of WWOX (P < 0.01), and progressive loss of FHIT and WWOX expression were observed as tumor differentiation decreased and tumor grade increased (P < 0.05). Absent/reduced FHIT and WWOX expression was associated with tumor invasion and metastasis (P < 0.05). In addition, the expression of FHIT and WWOX in HCC with recrudesce were lower than that in those without recrudesce (P < 0.05).</p><p><b>CONCLUSIONS</b>Absent/reduced FHIT and WWOX expression is associated with poor prognosis.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Oxidoreductases
/
Anatomopathologie
/
Pronostic
/
Acid anhydride hydrolases
/
Carcinome hépatocellulaire
/
Analyse de profil d'expression de gènes
/
Protéines suppresseurs de tumeurs
/
Oxydoréductase contenant des domaines WW
/
Génétique
/
Tumeurs du foie
Type d'étude:
Étude pronostique
Limites du sujet:
Adolescent
/
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Hepatology
Année:
2010
Type:
Article
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