Association of single nucleotide polymorphism in CYP17 and ERα genes with endometriosis risk in southern Chinese women / 中华医学遗传学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the association of single nucleotide polymorphisms in cytochrome P450 17 (CYP17) and estrogen receptor alpha (ERα ) genes with the risk of endometriosis among southern Chinese women.</p><p><b>METHODS</b>Two SNPs rs743572 (CYP17 gene 34T/C) and rs9322331 (ERα gene -397T/C) were genotyped by high resolution melting curve in 432 endometriosis patients and 499 matched controls.</p><p><b>RESULTS</b>There was no significant difference in the genotype frequencies of the two loci between endometriosis patients and the control subjects (P> 0.05). And there was no significant interaction effect of these two genes on the disease either.</p><p><b>CONCLUSION</b>CYP17 gene and ERα gene may not be genetic risk factors for endometriosis among southern women in China.</p>