CCR5, a new target of anti-HIV drugs / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 635-639, 2003.
Article
Dans Zh
| WPRIM
| ID: wpr-327019
Responsable en Bibliothèque :
WPRO
ABSTRACT
CCR5, a membrane protein on cell surface, is a member of the G protein-coupled receptor superfamily and one of the major co-receptors for HIV-1 infection. The roles of CCR5 in HIV-1 infection have been elucidated since 1996. Because of the biological nature of CCR5, it has became a molecular target for the novel drugs against HIV-1. Antagonists for CCR5 could be grouped as following, chemokine derivatives, small molecule non-peptide compounds, monoclonal antibodies and peptides. The latest progress in this field is reviewed in this article.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pharmacologie
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Conception de médicament
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Infections à VIH
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VIH-1 (Virus de l'Immunodéficience Humaine de type 1)
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Agents antiVIH
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Récepteurs aux chimiokines
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Récepteurs CCR5
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Antagonistes des récepteurs CCR5
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Métabolisme
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Anticorps monoclonaux
langue:
Zh
Texte intégral:
Acta Academiae Medicinae Sinicae
Année:
2003
Type:
Article