Influence of obesity on pharmacokinetics and pharmacodynamics of isoflurane / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 615-618, 2003.
Article
Dans Chinois
| WPRIM
| ID: wpr-327024
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effect of obesity on pharmacokinetics and pharmacodynamics of isoflurane.</p><p><b>METHODS</b>Twenty-six patients undergoing cholecystectomy were divided into obese group (Group A, BMI > or = 27, n = 13) and normal body weight group (Group N, BMI < or = 24, n = 13) according to body mass index (BMI). All patients were given to the same isoflurane anesthesia. Inspired and end-expired concentrations of isoflurane were monitored and uptake fraction of isoflurane were calculated.</p><p><b>RESULTS</b>Isoflurane concentrations of vaporizer in Group A [(1.8 +/- 0.3)%] were evidently higher than those in Group N [(1.5 +/- 0.1)%] at all observed points (P < 0.05 or P < 0.01). Uptake fraction of isoflurane in Group A were higher than those in Group N at observed points (P < 0.05, P < 0.01 or P < 0.001), but there were no differences in the time when isoflurane concentration was lowered to 50% and awake time between the two groups after discontinuing inhaling isoflurane.</p><p><b>CONCLUSIONS</b>Obese patients demand higher inspired concentration and uptake of isoflurane than those in normal weight patients but discharge of isoflurane was influenced by obesity within the observed period of (66 +/- 33) min.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacocinétique
/
Indice de masse corporelle
/
Cholécystectomie laparoscopique
/
Anesthésiques par inhalation
/
Relation dose-effet des médicaments
/
Isoflurane
/
Anesthésie par inhalation
/
Métabolisme
/
Obésité
Limites du sujet:
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Acta Academiae Medicinae Sinicae
Année:
2003
Type:
Article
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