Immunological effects of polyacrylamide hydrogel injection in human body / 中华整形外科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To observe the immunologic changes in patients who have complications after polyacrylamide hydrogel (HPG) injection.</p><p><b>METHODS</b>To compare the patients in the HPG injection group and the control group, the expressions of immunoglobulin IgG, IgM, IgA and complement C3, C4 of serum were measured by immunoturbidimetry.</p><p><b>RESULTS</b>The expressions of IgG and C3 in the injection group were lower than the control group with extremely significant difference (P < 0.01). The expressions of IgM were higher than the control group with significant difference (P < 0.05). The expression of IgA and C4 had no significant differences between the two groups. The immunologic changes had no relation to the injection doses.</p><p><b>CONCLUSIONS</b>Clinical application of HPG as a soft tissue filling material may cause foreign-body rejection reaction. The long-term immunologic effect of HPG needs further observation in more cases.</p>