Role of mitochondria in the pathogenesis and treatment of glaucoma / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 4358-4365, 2013.
Article
Dans Anglais
| WPRIM
| ID: wpr-327571
ABSTRACT
<p><b>OBJECTIVE</b>To gain insight into the potential mechanism of mitochondria dysfunction in pathogenesis, progression and therapeutic management of glaucoma.</p><p><b>DATA SOURCES</b>The data used in this review were mainly published in English from 2000 to present obtained from PubMed. The search terms were "mitochondria", "glaucoma" and "trabecular meshwork" or "retinal ganglion cells".</p><p><b>STUDY SELECTION</b>Articles studying the mitochondria-related pathologic mechanism and treatment of glaucoma were selected and reviewed.</p><p><b>RESULTS</b>Mitochondrial dysfunction or injury was demonstrated in different eye tissue of glaucoma. A variety of potential injuries (light, toxic materials, oxidative injury, mechanical stress, aging, etc.) and the inherent DNA defects are deemed to cause mitochondrial structural and functional destruction in trabecular meshwork cells, retinal ganglion cells, etc. of glaucoma. In addition, various new experimental and therapeutic interventions were used to preserve mitochondrial function, which may be useful for protecting against optic nerve degeneration or reducing the death of retinal ganglion cells in glaucoma.</p><p><b>CONCLUSIONS</b>Mitochondria play an important role in the pathogenesis of glaucoma, various strategies targeting mitochondrial protection might provide a promising way to delay the onset of glaucoma or protect RGCs against glaucomatous damage.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Cellules ganglionnaires rétiniennes
/
Réseau trabéculaire de la sclère
/
Glaucome
/
Métabolisme
/
Mitochondries
Type d'étude:
Etude d'étiologie
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Chinese Medical Journal
Année:
2013
Type:
Article
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