Research Advances in the Role of Bromodomain-containing Protein 4 in Epithelial-mesenchymal Transition in Asthma / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 425-431, 2017.
Article
Dans Anglais
| WPRIM
| ID: wpr-327801
ABSTRACT
Asthma is a chronic airway disease characterized by airway inflammation and airway remodeling. Chronic airway inflammation can be involved in airway remodeling in asthmatic patients by incuding epithelial-mesenchymal transition (EMT).Bromodomain-containing protein 4 (BRD4) is a key transcriptional regulator in mammals,and many evidences have shown that BRD4 plays a pivotal role in airway remodeling via nuclear factor-κB/RelA signaling pathway. This review summarizes the recent advances in the role of BRD4 in regulating EMT,with an attempt to elucidate the molecular mechanisms of asthma and inform the prevention and control of asthma.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Anglais
Texte intégral:
Acta Academiae Medicinae Sinicae
Année:
2017
Type:
Article
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