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Preparation of herpetin lyophilized liposome and evaluation on its safety and pharmacodynamics / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 3065-3068, 2014.
Article Dans Chinois | WPRIM | ID: wpr-327842
ABSTRACT
In this study, the herpetin (HPT) lyophilized liposome was prepared, and its saftey and pharmacodynamics were evaluated. HPT lyophilized liposome was prepared by thin-film ultrasonication method. The lyoprotectant was optimized using particle size and encapsulation efficiency as indexes. Then, the influencing factors of HPT lyophilized liposome were investigated. In addition, preliminary safety and therapy efficiency of HPT lyophilized liposome to liver injury induced by CCl4 in the mice. The optimal lyoprotectant was 5% sucrose plus 5% lactose and the dispersed HPT lyophilized liposomes were spherical with the mean diameter of (107.0 ± 1.2) nm and the mean encapsulation efficiency of (99.7 ± 0.50)%. The lyophilized powder was sensitive to temperature, humidity and illumination. None of hemolysis, hemagglutination and vein irritation was observed after intravenous injection of HPT lyophilized liposomes into rabbits. HPT lyophilized liposome showed obviously therapy efficiency to liver injury induced by CCl4 in the mice. The improvements of ALT, AST and ALP were better than that in HPT free drug. The obtained HPT lyophilized liposome met the standard of CP with fine particle size and encapsulation efficiency after dispersion. The HPT lyophilized liposome showed good safety and enhanced the treatment efficacy of HPT. The HPT lyophilized liposome should be stored in low temperature, sealed condition far away from light.
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Vecteurs de médicaments / Médicaments issus de plantes chinoises / Pharmacocinétique / Chimie / Chimie pharmaceutique / Cucurbitaceae / Évaluation préclinique de médicament / Stabilité de médicament / Liposomes / Souris de lignée ICR Limites du sujet: Animaux langue: Chinois Texte intégral: China Journal of Chinese Materia Medica Année: 2014 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Vecteurs de médicaments / Médicaments issus de plantes chinoises / Pharmacocinétique / Chimie / Chimie pharmaceutique / Cucurbitaceae / Évaluation préclinique de médicament / Stabilité de médicament / Liposomes / Souris de lignée ICR Limites du sujet: Animaux langue: Chinois Texte intégral: China Journal of Chinese Materia Medica Année: 2014 Type: Article