Study of trisomy 22 and inversion 16 in acute myeloid leukemia / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 11-14, 2007.
Article
Dans Chinois
| WPRIM
| ID: wpr-328381
ABSTRACT
<p><b>OBJECTIVE</b>To explore the value of trisomy 22 ( +22) in the diagnosis of inv(16) acute myeloid leukemia (AML).</p><p><b>METHODS</b>Interphase fluorescence in situ hybridization (FISH) was performed in 18 AML patients with +22. The probe was two-color break apart probe for CBFbeta with SpectrumRed on the centromeric side and SpectrumGreen on the telomeric side. The FISH results were compared with that of R-banding conventional cytogenetics (CC). Multiplex FISH (M-FISH) was used to analyze the relationship of +22 and inv(16).</p><p><b>RESULTS</b>CC revealed inv(16) in none of the 18 AML, with +22, but FISH revealed inv (16) in 11 of them and del( 16) (q22) in one. As CC results, 9 of the 11 cases were sole +22, one complicated with trisomy 8, and one del(16) (q22). Four patients with +22 and inv(16) were analyzed by M-FISH and revealed +22 only.</p><p><b>CONCLUSION</b>+22 can be regarded as an important marker for the diagnosis of inv(16) AML.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Trisomie
/
Chromosomes humains de la paire 16
/
Chromosomes humains de la paire 22
/
Leucémie aigüe myéloïde
/
Hybridation fluorescente in situ
/
Génétique
/
Inversion chromosomique
Limites du sujet:
Adolescent
/
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Hematology
Année:
2007
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS