Potential synergistic and multitarget effect of herbal pair Chuanxiong Rhizome-Paeonia Albifora Pall on osteoarthritis disease: a computational pharmacology approach / 中国结合医学杂志
Chinese journal of integrative medicine
; (12): 698-703, 2011.
Article
de En
| WPRIM
| ID: wpr-328430
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the polypharmacological mechanism of herbal pair Chuanxiong Rhizome-Paeonia Albifora Pall (HP CXR-PAP) on the treatment for osteoarthritis (OA).</p><p><b>METHODS</b>Chemical space was used to discuss the similarities and differences between the molecule sets of HP CXR-PAP and drugs. Docking protocol was used to study the interaction between HP CXR-PAP and OA target enzymes. The similarities and differences of HP CXR-PAP and drugs in target spaces were elucidated by network features.</p><p><b>RESULTS</b>The plots between the molecule sets of HP CXR-PAP and drugs in chemical space had the majority in the same region, and compounds from HP CXR-PAP covered a much larger additional region of space than drug molecules, which denoted the diverse structural properties in the molecule set of HP CXR-PAP. The molecules in HP CXR-PAP had the properties of promiscuous drugs and combination drug, and both HP CXR-PAP ligand-target interaction network and drug ligand-target interaction network were similar in the interaction profiles and network features, which revealed the effects of multicomponent and multitarget.</p><p><b>CONCLUSION</b>The clue of potential synergism was obtained in curing OA disease by Chinese medicine, which revealed the advantages of Chinese medicine for targeting osteoarthritis disease.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Arthrose
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Pharmacologie
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Médicaments issus de plantes chinoises
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Modèles moléculaires
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Analyse en composantes principales
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Utilisations thérapeutiques
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Association médicamenteuse
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Synergie des médicaments
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Traitement médicamenteux
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Association de médicaments
Type d'étude:
Guideline
Limites du sujet:
Humans
langue:
En
Texte intégral:
Chinese journal of integrative medicine
Année:
2011
Type:
Article