Changes of HLA-DR15 and immunoglobulin, T lymphocyte subsets in patients with aplastic anemia, myelodysplastic syndrome and their significance / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 111-115, 2010.
Article
Dans Zh
| WPRIM
| ID: wpr-328562
Responsable en Bibliothèque :
WPRO
ABSTRACT
The objective of this study was to detect the expression frequency of HLA-DR15 in patients with aplastic anemia (AA) and myelodysplastic syndrome (MDS), to investigate the relation of expression frequency with diseases and to analyze the relationship between immunoglobulin, T lymphocyte subsets and HLA-DR15. HLA-DR15 expression was detected by PCR-SSP; immunoglobulin was detected by immune turbidimetry; T cell subsets were detected by flow cytometry. The results showed that the expression rates of HLA-DR15 in AA and MDS as well as normal control groups were 78.6%, 63.2% and 24.6% respectively. The difference between AA, MDS and the normal control groups was statistically significant (p < 0.01). OR (odds ratios) values of AA and MDS groups were 11.262, 4.710 respectively. Compared with normal control group, expression rate of HLA-DR15 in hematologic malignancy group was not significantly different. The immunoglobulin level and abnormal T cell subsets in AA and MDS groups were statistically different between HLA-DR15 positive and negative groups (p > 0.05). It is concluded that the frequency of HLA-DR15 antigen in AA and MDS patients is significantly higher than that in normal control and hematologic malignancy group. OR value>1 showed a positive correlation between the diseases and HLA-DR15. HLA-DR15 is a susceptible gene in AA and MDS. The abnormalities of immunoglobulin level and ratios of T cell subsets in AA and MDS are common, but are not associated significantly with the expression of HLA-DR15.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Syndromes myélodysplasiques
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Immunoglobulines
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Test d'histocompatibilité
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Antigènes HLA-DR
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Études cas-témoins
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Sous-populations de lymphocytes T
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Allergie et immunologie
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Sous-types sérologiques HLA-DR
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Cytométrie en flux
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Anémie aplasique
Type d'étude:
Observational_studies
/
Risk_factors_studies
Limites du sujet:
Adolescent
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Adult
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Aged
/
Aged80
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Female
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Humans
/
Male
langue:
Zh
Texte intégral:
Journal of Experimental Hematology
Année:
2010
Type:
Article