Research progress on gene mutation of jak2 / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1629-1632, 2009.
Article
Dans Chinois
| WPRIM
| ID: wpr-328585
ABSTRACT
Chronic myeloproliferative disease (CMPD) is a group of malignant blood disorders including polycythemia vera, essential thrombocythemia, primary myelofibrosis, chronic myeloid leukemia, and so on. CMPD is characterized by proliferation of one or several lineages in hematopoietic system. The pathogenesis of CMPD is not clear except chronic myeloid leukemia associated with the bcr/abl fusion gene. In recent years, more studies demonstrated that CMPD have a higher mutation rate of gene jak2. In this review, the association of jak2 gene mutation with clinical diagnosis, clinical feature and molecular target therapy in CMPD and other hematological disease were summarized.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Maladie chronique
/
Kinase Janus-2
/
Maladies myélodysplasiques-myéloprolifératives
/
Génétique
/
Mutation
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Journal of Experimental Hematology
Année:
2009
Type:
Article
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