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Clinical and biological characteristics in childhood acute myeloid leukemia with 8;21 translocation / 中华医学遗传学杂志
Chinese Journal of Medical Genetics ; (6): 512-514, 2004.
Article Dans Chinois | WPRIM | ID: wpr-328836
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the clinical and biological characteristics of childhood acute myeloid leukemia(AML)with 8;21 translocation.</p><p><b>METHODS</b>A retrospective analysis including clinical information, cell morphology, chromosome, immunophenotype and molecular biology was performed on 41 cases of childhood t(8;21)AML. The control group included 19 cases of AML without t(8;21) translocation detected during the same period.</p><p><b>RESULTS</b>The 41 cases of t(8;21)AML accounted for 68.3% of 60 continuous childhood AML patients. Among them, classical t(8;21) translocation was seen in 29 cases; variant t(8;21) translocation, simple 8q-, near-tetraploidy characterized by the duplication of t(8;21) translocation each came into view in 2 cases; and cryptic t(8;21) translocation was seen in 6 cases. Thirty seven cases (80.4%) belonged to M2 subtype of AML. Most of them had the morphological changes such as the leukemia cells' indent nucleus with a light stain region of perinucleus, basophilic cytoplasm, differentiation with maturation, megaloblastoid changes and nuclear-cytoplasm imbalance; the high expression of CD13 antigen; and the AML1/ETO fusion transcript in 23 cases examined by reverse transcription-polymerase chain reaction (RT-PCR) assay, including 6 cases with normal karyotype. The difference in complete remission rate between t(8;21) positive patients group and t(8;21) negative patients group was not significant in statistics (82.4% vs 75%, P>0.05). However the difference in recurring rate of the leukemia was statistically significant (10.7% vs 41.7%, P<0.05).</p><p><b>CONCLUSION</b>t(8;21)AML is the most frequent type of childhood AML. It is predominantly associated with M2 subtype of AML and has unique morphological, immunological prognostic features .</p>
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Anatomopathologie / Translocation génétique / Chromosomes humains de la paire 8 / Chromosomes humains de la paire 21 / Leucémie myéloïde / Maladie aigüe / Études rétrospectives / RT-PCR / Génétique / Caryotypage Type d'étude: Étude observationnelle / Étude pronostique Limites du sujet: Adolescent / Enfant / Enfant d'âge préscolaire / Femelle / Humains / Mâle langue: Chinois Texte intégral: Chinese Journal of Medical Genetics Année: 2004 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Anatomopathologie / Translocation génétique / Chromosomes humains de la paire 8 / Chromosomes humains de la paire 21 / Leucémie myéloïde / Maladie aigüe / Études rétrospectives / RT-PCR / Génétique / Caryotypage Type d'étude: Étude observationnelle / Étude pronostique Limites du sujet: Adolescent / Enfant / Enfant d'âge préscolaire / Femelle / Humains / Mâle langue: Chinois Texte intégral: Chinese Journal of Medical Genetics Année: 2004 Type: Article