The Effect of Curcumin and Human Adipose-derived Stromal Cells on Wound Healing of Lewis Rats

ABSTRACT

PURPOSE: On this study, we investigated the effects of curcumin and adipose-derived stromal cells(ADSCs) in wound healing process, especially in the aspect of synergic effects when they were administrated simultaneously. METHODS: Curcumin(40mg/kg) and/or 1.0x10(6) ADSCs were applied to an 1.5x1.5cm-sized full thickness wound on the backs of male Lewis rats(n=5 in each group). In control group(n=5), saline was administrated instead of curcumin and ASCs. The wound size was followed by computer planimetry in 5, 7, and 14 days, and wounds were harvested for histological analysis in 7 and 14 days. RESULTS: The dimensions of wounds of curcumin, ADSCs, and curcumin-ADSCs group significantly decreased in 5, 7, 14 days compared with those of control group(p0.05). There were infiltration of more epithelization and more precisely organization of extracellular matrix in curcumin, ADSCs, and curcumin-ADSCs group compared with those of control group. CONCLUSION: The results suggest that curcumin and ADSCs have beneficial effects in the acceleration of wound healing. Although the simultaneous application of curcmin and ADSCs also has beneficial effects on wound healing, there are no significant synergic effects.