Study of in vivo micronucleus formation in lymphocytes from the patients and its relation to malignant degrees of colorectal cancer / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 365-367, 2004.
Article
Dans Chinois
| WPRIM
| ID: wpr-328876
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association of the micronucleus (MN) formation in lymphocytes from patients with the malignant degrees of colorectal cancer.</p><p><b>METHODS</b>The MN test in capillary blood lymphocytes was conducted in 112 patients randomly selected from in-hospital patients before therapy. Experimental data were analyzed by SPSS (v.10.1) software.</p><p><b>RESULTS</b>The differences in the frequency of MN between 7 pathological types of colorectal cancers and controls were statistically significant (P<0.01). The frequency of MN increased with the decrease of the histological differentiation in colorectal cancer, and the statistically significant differences were seen between low differentiation group and the other differentiation groups in colorectal cancers.</p><p><b>CONCLUSION</b>There is a significant correlation between MN formation and the malignant degrees of colorectal cancer, and MN formation will be a useful biomarker for the identification of malignant degrees of colorectal cancer before operation or for the screening of high risk subgroup.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Sang
/
Lymphocytes
/
Tumeurs colorectales
/
Tests de micronucleus
/
Génétique
/
Métabolisme
/
Méthodes
Limites du sujet:
Adulte
/
Adulte très âgé
/
Aged80
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Medical Genetics
Année:
2004
Type:
Article
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