Study on gamma-synuclein gene in patients with idiopathic Parkinson's disease / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 444-446, 2003.
Article
Dans Chinois
| WPRIM
| ID: wpr-329438
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the relationship between idiopathic Parkinson's disease (PD) and two polymorphisms (C243G and A377T) of the gamma-synuclein gene in a Chinese Han population of Shanghai area.</p><p><b>METHODS</b>Polymorphic genotyping was performed with PCR-RPLP technique. Association analysis was carried out in 145 unrelated idiopathic PD patients and 184 age-matched healthy controls.</p><p><b>RESULTS</b>The authors failed to detect any distributional difference of the C243G and A377T polymorphisms of the gamma-synuclein gene between PD cases and control subjects, nor did they find any association.</p><p><b>CONCLUSION</b>These data do not support that gamma-synuclein gene C243G and A377T polymorphisms are involved in idiopathic PD onset in the Han population of Shanghai area.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Maladie de Parkinson
/
Polymorphisme de nucléotide simple
/
Allèles
/
Synucléines
/
Gamma-Synucléine
/
Fréquence d'allèle
/
Génétique
/
Génotype
/
Protéines de tissu nerveux
Limites du sujet:
Adulte
/
Adulte très âgé
/
Aged80
/
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Medical Genetics
Année:
2003
Type:
Article
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