Transmission disequilibrium test of polymorphisms of serotonin transporter gene and schizophrenia based on family trios / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 342-344, 2003.
Article
Dans Chinois
| WPRIM
| ID: wpr-329466
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between two polymorphisms (Intronic VNTR and 5-HTTLPR) of the serotonin transporter gene and schizophrenia.</p><p><b>METHODS</b>A set of 314 schizophrenic trio samples collected from Shanghai, Xi'an and Jilin regions of China independently was subjected to analysis of the polymorphisms by transmission/disequilibrium test(TDT).</p><p><b>RESULTS</b>No significantly preferential transmission of any allele was detected from both polymorphisms investigated.</p><p><b>CONCLUSION</b>The results suggest that the serotonin transporter gene is unlikely to have a major contribution to susceptibility to schizophrenia in Han Chinese population.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Polymorphisme génétique
/
Schizophrénie
/
Famille nucléaire
/
Réaction de polymérisation en chaîne
/
Répétitions minisatellites
/
Prédisposition génétique à une maladie
/
Transporteurs de la sérotonine
/
Génétique
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Medical Genetics
Année:
2003
Type:
Article
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