Correlation of CKP and VEGF expression and microvessel density to spiral CT manifestations of thymoma / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1896-1899, 2010.
Article
Dans Chinois
| WPRIM
| ID: wpr-330811
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the correlation of cytokeratin pan (CKP), vascular endothelial growth factor (VEGF) expression and microvessel density (MVD) to spiral CT manifestations of thymoma.</p><p><b>METHODS</b>Eighty-four thymoma patients were underwent spiral CT examination, and 40 of the patients also had enhanced CT examination. All the CT findings were carefully reviewed to analyze their correlation to the expressions of CKP, VEGF and MVD.</p><p><b>RESULTS</b>The enhancement on spiral CT images increased with the levels of VEGF expression and MVD counting (P<0.01). Significant correlations were observed between VEGF expression, MVD counting and such spiral CT findings as lobular contours, cusp-like or sawtooth-like margins and tumor invasions of the pleural membrane, pericardium and great vessels (P<0.05). CKP expression showed no obvious correlation to these findings by spiral CT.</p><p><b>CONCLUSION</b>Spiral CT can reflect the pathological characteristics of thymoma, and may serve as a noninvasive modality for preoperative evaluation of thymoma.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Thymome
/
Tumeurs du thymus
/
Imagerie diagnostique
/
Tomodensitométrie hélicoïdale
/
Facteur de croissance endothéliale vasculaire de type A
/
Microvaisseaux
/
Génétique
/
Kératines
/
Métabolisme
Type d'étude:
Etude diagnostique
Limites du sujet:
Adolescent
/
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Journal of Southern Medical University
Année:
2010
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS