Expression of pituitary tumor transforming gene in human renal clear cell carcinoma and its significance / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1712-1714, 2010.
Article
Dans Chinois
| WPRIM
| ID: wpr-330850
ABSTRACT
<p><b>OBJECTIVE</b>To explore the expression of pituitary tumor transforming gene (PTTG) in human renal clear cell carcinoma (RCCC) and its significance.</p><p><b>METHODS</b>PTTG protein expression was detected by immunohistochemistry in 87 RCCC and 45 paired normal renal tissues.</p><p><b>RESULTS</b>PTTG was expressed differentially between the normal renal and RCCC tissues. Compared with normal tissues, the primary RCCC tissues showed significantly increased expression of PTTG protein (P<0.001). The positive rate of PTTG protein was positively correlated to the tumor size, clinical stage and Fuhrman grade of RCCC (P=0.009, 0.008 and 0.035, respectively).</p><p><b>CONCLUSION</b>Increased PTTG protein expression may be involved in the carcinogenesis and progression of RCCC.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Immunohistochimie
/
Néphrocarcinome
/
Régulation de l'expression des gènes tumoraux
/
Sécurine
/
Génétique
/
Tumeurs du rein
/
Métabolisme
/
Protéines tumorales
Limites du sujet:
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Journal of Southern Medical University
Année:
2010
Type:
Article
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