Simultaneous determination of ibuprofen and pseudoephedrin hydrochloride and chlorpheniramine maleate in the compound buluoweimanamin tablets by HPLC / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>An HPLC method was developed to determinate Ibuprofen and Pseudoephedrine Hydrochloride and Chlorpheniramine Maleate in Compound BuluoWeimaNamin Tablets.</p><p><b>METHODS</b>Using HPLC with Kromasil C18 column, and acetonitrile -0.5% SDS- phosphate (5804201) as the mobile phase. The wavelength for detection was 262 nm.</p><p><b>RESULTS</b>Better linearities and good correlation coefficients were obtained the concentration ranges of ibuprofen, pseudoephedrine hydrochloride and chlorpheniramine maleate were over 2.062-14.434 microg (r=0.9999), 0.296-2.072l microg (r=0.9999), and 0.0204~0.1428 microg (r=0.9998), respectively. The recoveries of ibuprofen, pseudoephedrine hydrochloride and chlorpheniramine maleate were 99.98% (RSD=0.52%), 99.72 (RSD=0.82%) and 99.545 (RSD=0.76%), respectively.</p><p><b>CONCLUSION</b>The method was convenient, accurate and specific. It can be used as a method to control quality of Compound Buluoweimanamin Tablets.</p>