The action of decorin in anti-fibrosis and anti-cancer / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 222-225, 2007.
Article
Dans Chinois
| WPRIM
| ID: wpr-331360
ABSTRACT
Decorin (DCN) is a member of the small leucine-rich proteoglycan gene family. Many studies indicated that DCN inhibited fibrosis and scar-formation by neutralization of TGF-P and interfering the binding of TGF-beta with its receptor, which induced ectopic deposition of extracellular matrix. Additionally, DCN can prevent the proliferation and metastasis of tumor cells by activating EGFR/MAPK/p21 signal pathway and inhibiting the cell proliferation pathway mediated by EGF-EGFR. It is suggested that the recombinant DCN had potential pharmaceutical potency in treatment of chronic fibrosis and neoplasm for its critical biological activities and low immunogenicity.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Protéoglycanes
/
Fibrose
/
Protéines recombinantes
/
Chimie
/
Protéines de la matrice extracellulaire
/
Facteur de croissance transformant bêta-1
/
Décorine
/
Récepteurs ErbB
/
Antinéoplasiques
Limites du sujet:
Animaux
/
Humains
langue:
Chinois
Texte intégral:
Journal of Biomedical Engineering
Année:
2007
Type:
Article
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