A parental case control study on the association between reduced folate carrier gene polymorphism and neural tube defects / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 665-668, 2005.
Article
Dans Chinois
| WPRIM
| ID: wpr-331811
ABSTRACT
<p><b>OBJECTIVE</b>To study the association between reduced folate carrier gene (RFC1 A80G) polymorphism and the risk for child with neural tube defects (NTDs), and to provide epidemiological evidence for the existence of NTDs genetic marker.</p><p><b>METHODS</b>RFC1 (A80G) genotypes were detected using RFLP-PCR for blood DNA of 104 families with NTDs-affected children and 100 control families with no history of child-affected birth defects. Case-control study and transmission/disequilibrium test(TDT) for the RFC1 genotype of NTDs pedigree were carried out.</p><p><b>RESULTS</b>The G allele frequency of children with NTDs was higher than that of controls when compared to A allele( OR = 1. 64, 95% CI1.08-2.49). The offspring of the GG genotype were associated with a 2.56-fold increased risk of NTDs when compared to the AA genotype (OR = 2.56, 95% CI 1.04-6.36) in our study population. There was evidence of association between G allele and the risk of parent having a child with NTDs (OR = 1.56, 95% CI 1.07-2.28) in the TDT analysis.</p><p><b>CONCLUSION</b>Our findings indicated that there was potential association between offspring RFC1 GG genotype and the risk of NTDs, and the G allele was a possible susceptible gene marker for an increased NTDs risk in the Chinese population.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Parents
/
Protéines de transport membranaire
/
Polymorphisme génétique
/
Études cas-témoins
/
Prédisposition génétique à une maladie
/
Protéine de transport de folate réduit
/
Fréquence d'allèle
/
Génétique
/
Génotype
/
Anomalies du tube neural
Type d'étude:
Étude observationnelle
/
Facteurs de risque
Limites du sujet:
Enfant
/
Enfant d'âge préscolaire
/
Femelle
/
Humains
/
Bébé
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Epidemiology
Année:
2005
Type:
Article
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