Study on the safety and immunogenicity of enterotoxigenic Escherichia coli recombinant active vaccine / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 515-519, 2005.
Article
Dans Chinois
| WPRIM
| ID: wpr-331845
ABSTRACT
<p><b>OBJECTIVE</b>To study the safety, immunogenicity on the enterotoxige Escherichia coli (E. coli) recombinant active vaccine FE3 and FE16.</p><p><b>METHODS</b>Toxicity and immunogenicity of the vaccine were determined by experiments on enterotoxigenic E. coli toxicity and immunological experiments on rabbits and mice.</p><p><b>RESULTS</b>The results of an toxicological experiments were negative. The agglutination titer of antibodies against the S. flexneri 2a and enterotoxigenic E. coli plamid antigen were all higher than 1640 and 11280 in the sera of rabbits. IgG in the serum went up remarkably, while sIgA against CFA/I was also decteted in the dejecta of mice immunized with active bacteria either orogastrically or intranasally. Simultaneously, sIgA was not detected in the dejecta of mice immunized with inactive bacteria either orogastrically or intranasally.</p><p><b>CONCLUSION</b>The enterotoxigenic E. coli recombinant active vaccine showed good safety and immunogenicity, inducing both humoral and mucosal immunity in mice.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Sang
/
Immunoglobuline A
/
Immunoglobuline G
/
Administration par voie nasale
/
Vaccins antibactériens
/
Vaccins synthétiques
/
Administration par voie orale
/
Agglutination
/
Effets secondaires indésirables des médicaments
/
Allergie et immunologie
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Chinese Journal of Epidemiology
Année:
2005
Type:
Article
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